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Description is the pattern of narrative development that aims to make vivid a place, object, character, or group. Description is one of four rhetorical mod

Affect in Online Discourse
Affect in Online Discourse
Affect in Online Discourse


Foreword

Peter C. Doherty, in Fenner and White's Medical Virology (Fifth Edition), 2017
Basic virology has, of course, been well served by the many revisions of Bernie Fields’ (1938–1995) exhaustive text and, following the example set by Field’s Virology, the fifth edition will appear as Fenner and White’s Medical Virology. It is a fitting tribute. Taken together, the original authors, and those responsible for this latest version, have variously been active and publishing on one or the other aspect of virus-induced disease and/or pathology since 1948: and the virology lineage goes back even further!


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Introduction

In Viral Pathogenesis (Third Edition), 2016
Virology, together with all of biomedical sciences, is undergoing a revolution that can be encapsulated as a transition from reductionism to systems biology. This third edition of Viral Pathogenesis reflects this paradigm shift and the new perspective it brings to the field. Accordingly, this edition is organized in four different parts: (I) History and essentials of viral pathogenesis; (II) Systems-level approaches to viral pathogenesis; (III) Emergence and control of viral infections; and (IV) Past and future. Part I sets forth our knowledge based on long-established methods in pathology, virology, and adaptive immunity. This section provides the background for the rest of the book, which focuses on current and future methods and discoveries in viral pathogenesis.


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Adult T-Cell Leukemia-Lymphoma

Kunihiro Tsukasaki, ... Kensei Tobinai, in Abeloff's Clinical Oncology (Fifth Edition), 2014

Virology and Pathogenesis

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HTLV-I is reverse-transcribed into DNA and randomly integrated into the host cell.

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The HTLV-I genome encodes two unique regulatory proteins—Tax and Rex—responsible for viral expression and cellular transformation. Tax trans-activates viral and cellular genes that could be involved in the pathogenesis of ATL. HTLV-I basic leucine zipper (HTLV-I bZIP; HBZ) is an antisense transcript of HTLV-I, is steadily expressed in ATL cells, and interacts with several host genes and suppresses the activity of Tax.

Foreword

Peter C. Doherty, in Fenner and White's Medical Virology (Fifth Edition), 2017
Basic virology has, of course, been well served by the many revisions of Bernie Fields’ (1938–1995) exhaustive text and, following the example set by Field’s Virology, the fifth edition will appear as Fenner and White’s Medical Virology. It is a fitting tribute. Taken together, the original authors, and those responsible for this latest version, have variously been active and publishing on one or the other aspect of virus-induced disease and/or pathology since 1948: and the virology lineage goes back even further!

Foreword

Peter C. Doherty, in Fenner and White's Medical Virology (Fifth Edition), 2017
Basic virology has, of course, been well served by the many revisions of Bernie Fields’ (1938–1995) exhaustive text and, following the example set by Field’s Virology, the fifth edition will appear as Fenner and White’s Medical Virology. It is a fitting tribute. Taken together, the original authors, and those responsible for this latest version, have variously been active and publishing on one or the other aspect of virus-induced disease and/or pathology since 1948: and the virology lineage goes back even further!

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